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The largest decrease occurred in 65-70 year old male respondent, namely 9.6 percent, while in women the same age only 7.4 percent. Study leader of the Centre for Epidemiology and Public Health Research France, Archana Singh-Manoux, told the BBC, Friday (6/1), said the study proves cognitive decline for 20-30 years can lead to dementia (memory loss). Higher rates of dementia would if the patient smoked.